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Cellular and molecular mechanisms of antimony transport, toxicity and resistance

Review article
Authors Markus J. Tamás
Published in Environmental Chemistry
Volume 13
Issue 6
Pages 955 - 962
ISSN 1448-2517
Publication year 2016
Published at Department of Chemistry and Molecular Biology
Pages 955 - 962
Language en
Subject categories Microbiology, Cell Biology, Biochemistry and Molecular Biology, Biological Sciences


Antimony is a toxic metalloid that is naturally present in low amounts in the environment, but can locally reach high concentrations at mining and processing sites. Today, antimony is used in a wide range of modern technology applications and is also an important constituent of pharmacological drugs. The increasing use of antimony has led to concerns about human and environmental exposure. Yet little is known about the biological properties of antimony and its mechanisms of actions in cells. This review will provide a brief summary of how antimony enters and affects cells, and how cells deal with the presence of this metalloid to acquire resistance.

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