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Increased Intimal Hyperplasia After Vascular Injury in Male Androgen Receptor-Deficient Mice

Journal article
Authors Anna S K Wilhelmson
Johan Bourghardt Fagman
Inger Johansson
Zhiyuan V. Zou
Axel G Andersson
Elin Svedlund Eriksson
Maria E Johansson
Per Lindahl
Per Fogelstrand
Åsa Tivesten
Published in Endocrinology
Volume 157
Issue 10
Pages 3915-3923
ISSN 1945-7170
Publication year 2016
Published at Wallenberg Laboratory
Institute of Clinical Sciences, Department of Surgery
Institute of Neuroscience and Physiology, Department of Physiology
Sahlgrenska Cancer Center
Institute of Medicine
Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 3915-3923
Language en
Links dx.doi.org/10.1210/en.2016-1100
https://gup.ub.gu.se/file/206715
Subject categories Basic Medicine

Abstract

Intimal hyperplasia is a vascular pathological process involved in the pathogenesis of atherosclerosis. Data suggest that T, the most important sex steroid hormone in males, protects men from atherosclerotic cardiovascular disease. T mainly acts via the androgen receptor (AR), and in this study we evaluated formation of intimal hyperplasia in male AR knockout (ARKO) mice using a vascular injury model. Two weeks after ligation of the carotid artery, male ARKO mice showed increased intimal area and intimal thickness compared with controls. After endothelial denudation by an in vivo scraping injury, there was no difference in the reendothelialization in ARKO compared with control mice. Ex vivo, we observed increased outgrowth of vascular smooth muscle cells from ARKO compared with control aortic tissue explants; the number of outgrown cells was almost doubled in ARKO. In vitro, stimulation of human aortic vascular smooth muscle cells with a physiological T concentration inhibited both migration and proliferation of the cells. Analyzing the expression of central regulators of cell proliferation and migration, we found that mRNA and protein levels of p27 were lower in uninjured arteries from ARKO mice and that T replacement to castrated male mice increased p27 mRNA in an AR-dependent manner. In conclusion, AR deficiency in male mice increases intimal hyperplasia in response to vascular injury, potentially related to the effects of androgens/AR to inhibit proliferation and migration of smooth muscle cells.

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