To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Naphthalene Derivatives f… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Naphthalene Derivatives from the Roots of Pentas parvifolia and Pentas bussei

Journal article
Authors Negera Abdissa
F. Pan
Amra Gruhonjic
Jürgen Gräfenstein
Paul A. Fitzpatrick
Göran Landberg
K. Rissanen
A. Yenesew
Mate Erdelyi
Published in Journal of natural products
Volume 79
Issue 9
Pages 2181-2187
ISSN 0163-3864
Publication year 2016
Published at Sahlgrenska Cancer Center
Swedish NMR Centre at Göteborg University
Department of Chemistry and Molecular Biology
Pages 2181-2187
Language en
Subject categories Inorganic Chemistry, Structural Biology


The phytochemical investigation of the CH2Cl2/MeOH (1:1) extract of the roots of Pentas parvifolia led to the isolation of three new naphthalenes, parvinaphthols A (1), B (2), and C (3), two known anthraquinones, and five known naphthalene derivatives. Similar investigation of the roots of Pentas bussei afforded a new polycyclic naphthalene, busseihydroquinone E (4), a new 2,2′-binaphthralenyl-1,1′-dione, busseihydroquinone F (5), and five known naphthalenes. All purified metabolites were characterized by NMR and MS data analyses, whereas the absolute configurations of 3 and 4 were determined by single-crystal X-ray diffraction studies. The E-geometry of compound 5 was supported by DFT-based chemical shift calculations. Compounds 2-4 showed marginal cytotoxicity against the MDA-MB-231 human triple-negative breast cancer cell line with IC50 values ranging from 62.3 to 129.6 μM. © 2016 The American Chemical Society and American Society of Pharmacognosy.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?