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Glial and neuronal markers in cerebrospinal fluid in different types of multiple sclerosis

Journal article
Authors M. A. Mañé-Martínez
Bob Olsson
L. Bau
E. Matas
Á Cobo-Calvo
Ulf Andreasson
Kaj Blennow
L. Romero-Pinel
S. Martínez-Yélamos
Henrik Zetterberg
Published in Journal of Neuroimmunology
Volume 299
Pages 112-117
ISSN 0165-5728
Publication year 2016
Published at Institute of Neuroscience and Physiology
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 112-117
Language en
Subject categories Neurology, Clinical Laboratory Medicine


In the present study, CSF concentrations of NFL, t-tau, p-tau, GFAP, S-100B, YKL-40, MCP-1, α-sAPP, β-sAPP, and Aβ38, Aβ40, Aβ42 were measured in 324 MS patients to test whether a correlation among the biomarkers exists and whether the profile of CSF biomarkers varies among the different types of MS. The CSF concentrations of NFL were significantly higher in RRMS while CSF concentrations of GFAP were higher in PPMS. CSF concentrations of NFL correlated with YKL-40 in CIS patients while CSF concentrations of GFAP correlated with YKL-40 in RRMS patients. © 2016 Elsevier B.V.

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