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High-NaCl Diet Aggravates Cardiac Injury in Rats with Adenine-Induced Chronic Renal Failure and Increases Serum Troponin T Levels

Journal article
Authors Pavlos Kashioulis
Ola Hammarsten
Niels Marcussen
Emman Shubbar
Aso Saeed
Gregor Guron
Published in Cardiorenal Medicine
Volume 6
Issue 4
Pages 317-327
ISSN 1664-3828
Publication year 2016
Published at Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine
Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 317-327
Language en
Links dx.doi.org/10.1159/000446547
Keywords Chronic renal failure, Adenine, Hypertension, Left ventricular hypertrophy, Troponin T, High-sodium, CHRONIC KIDNEY-DISEASE, HEMODIALYSIS-PATIENTS, INTERSTITIAL FIBROSIS, ATHEROSCLEROSIS, INSUFFICIENCY, EPIDEMIOLOGY, HYPERTENSION, MECHANISMS, PROTEIN, DEATH
Subject categories Molecular medicine, Cardiovascular medicine

Abstract

Aims: To examine the effects of 2 weeks of high-NaCl diet on left ventricular (LV) morphology and serum levels of cardiac troponin T (cTnT) in rats with adenine-induced chronic renal failure (ACRF). Methods: Male Sprague-Dawley rats either received chow containing adenine or were pair-fed an identical diet without adenine [controls (C)]. Approximately 10 weeks after the beginning of the study, the rats were randomized to either remain on a normal NaCl diet (NNa; 0.6%) or to be switched to high-NaCl chow (HNa; 4%) for 2 weeks, after which acute experiments were performed. Results: Rats with ACRF showed statistically significant increases (p < 0.001) in arterial pressure (AP), LV weight and fibrosis, and serum cTnT levels compared to controls. Two weeks of high-NaCl intake augmented the increases in AP, LV weight and fibrosis, and serum cTnT concentrations only in ACRF rats (p < 0.05 for group x NaCl intake interaction). Compared to group C-NNa, cTnT levels were elevated approximately 6-fold in group ACRF-NNa and 24-fold in group ACRF-HNa. Focal LV injury with cardiomyocyte necrosis, scarring, and fibrinoid necrosis of small arteries were only detected in group ACRF-HNa. There was a strong correlation between the degree of LV fibrosis and serum cTnT levels in ACRF rats (r = 0.81, p < 0.01). Conclusion: Two weeks of high-NaCl diet in rats with ACRF produces LV injury and aggravates increases in serum cTnT levels, presumably by causing hypertension-induced small artery lesions leading to myocardial ischemia. This model may be suitable for studying pathophysiological mechanisms in chronic renicardiac syndromes. (C) 2016 S. Karger AG, Basel

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