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One uterus bridging three generations: first live birth after mother-to-daughter uterus transplantation

Journal article
Authors Mats Brännström
Hans Bokström
Pernilla Dahm-Kähler
César Diaz-Garcia
Jana Ekberg
Anders Enskog
Henrik Hagberg
Liza Johannesson
Niclas Kvarnström
Johan Mölne
Michael Olausson
J. I. Olofsson
K. Rodriguez-Wallberg
Published in Fertility and Sterility
Volume 106
Issue 2
Pages 261-266
ISSN 0015-0282
Publication year 2016
Published at Institute of Clinical Sciences, Department of Surgery
Institute of Clinical Sciences, Department of Anesthesiology and Intensive care
Institute of Biomedicine, Department of Pathology
Institute of Clinical Sciences, Department of Obstetrics and Gynecology
Pages 261-266
Language en
Links dx.doi.org/10.1016/j.fertnstert.201...
Keywords Human, infertility, pregnancy, transplantation, uterus, VASCULAR ANASTOMOSIS, AUTOTRANSPLANTATION, LIVEBIRTH, PREGNANCY, TRIAL, MOUSE
Subject categories Transplantation surgery, Obstetrics and gynaecology

Abstract

Objective: To determine whether a uterus from the mother of a woman with absolute uterine factor infertility can be transplanted to daughter and carry a pregnancy with delivery of a healthy child. Patient(s): Twenty eight-year-old woman with uterine agenesis, her male partner, and her 50-year-old mother. Intervention(s): In vitro fertilization with embryo cryopreservation before live donor uterus transplantation (UTx). Induction immunosuppression. Embryo transfer 12 months after UTx, pregnancy controls, delivery, and hysterectomy. Main Outcome Measure(s): Results of IVF-ET, parameters of pregnancy/birth, and surgical data of transplantation/cesarean section/hysterectomy. Result(s): Two IVF cycles before UTx resulted in 10 cryopreserved embryos. Donor surgery included hysterectomy with vascular pedicles of uterine vessels and proximal vessels up to and including parts of internal iliacs. Recipient surgery was by bilateral vascular connections to external iliacs, vaginal-vaginal anastomosis, and uterine fixation. Pregnancy occurred at the first single ET, and the pregnancy proceeded uneventfully until gestational week 34, when the patient developed cholestasis with intense pruritus. Cesarean section was performed at 34+6, with delivery of a healthy boy (weight 2,335 g). Hysterectomy was performed 3.5 months after delivery. The weight of the healthy child at 12 months was 9.3 kg. Grandmother (uterus donor) and mother are in good health 3 years after UTx. Conclusion(s): This is the first report of a live birth after mother-to-daughter UTx, and it also represents the second birth ever after human UTx. (C) 2016 by American Society for Reproductive Medicine.

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