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Factors Influencing Early Dental Implant Failures

Journal article
Authors B. R. Chrcanovic
J. Kisch
Tomas Albrektsson
Ann Wennerberg
Published in Journal of Dental Research
Volume 95
Issue 9
Pages 995-1002
ISSN 0022-0345
Publication year 2016
Published at Institute of Clinical Sciences, Department of Biomaterials
Pages 995-1002
Language en
Links dx.doi.org/10.1177/0022034516646098
Keywords endosseous dental implantation, osseointegration, treatment outcome, adverse effects, survival rate, BONE-MINERAL DENSITY, DISTRACTION OSTEOGENESIS, SKELETAL DEVELOPMENT, CIGARETTE-SMOKING, GROWTH-FACTOR, SEROTONIN, NICOTINE, REGENERATION, EXPRESSION, DIFFERENTIATION
Subject categories Biomaterials

Abstract

The purpose of the present study was to assess the influence of local and systemic factors on the occurrence of dental implant failures up to the second-stage surgery (abutment connection). This retrospective study is based on 2,670 patients who received 10,096 implants and were consecutively treated with implant-supported prostheses between 1980 and 2014 at 1 specialist clinic. Several anatomic-, patient-, health-, and implant-related factors were collected. Descriptive statistics were used to describe the patients and implants. Univariate and multivariate logistic regression models were used at the patient level as well as the implant level to evaluate the effect of explanatory variables on the failure of implants up to abutment connection. A generalized estimating equation method was used for the implant-level analysis to account for the fact that repeated observations (several implants) were available for a single patient. Overall, 642 implants (6.36%) failed, of which 176 (1.74%) in 139 patients were lost up to second-stage surgery. The distribution of implants in sites of different bone quantities and qualities was quite similar between implants lost up to and after abutment connection. Smoking and the intake of antidepressants were the statistically significant predictors in the multivariate model (ClinicalTrials. gov NCT02369562).

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