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The Effect of Normovolemic and Hypervolemic Hemodilution on a Microsurgical Model: Experimental Study in Rats.

Journal article
Authors Matteo Amoroso
Özlenen Özkan
Ömer Özkan
Cumhur İbrahim Başsorgun
Önur Ögan
Kerim Ünal
Benedetto Longo
Fabio Santanelli di Pompeo
Published in Plastic and reconstructive surgery
Volume 136
Issue 3
Pages 512-9
ISSN 1529-4242
Publication year 2015
Published at
Pages 512-9
Language en
Keywords Animals, Female, Free Tissue Flaps, blood supply, Graft Survival, Hemodilution, methods, Microcirculation, Random Allocation, Rats, Rats, Wistar
Subject categories Plastic surgery


Nowadays, postoperative flap perfusion impairment still occurs in free flap surgery; despite several studies on microcirculatory physiology, the effect of hemodilution is still extremely controversial. The aim of this study was to investigate the impact of acute normovolemic and hypervolemic hemodilution on the incidence of flap survival rate in a microsurgical rat model.

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