To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Saturated Fatty Acids Ind… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Saturated Fatty Acids Induce c-Src Clustering within Membrane Subdomains, Leading to JNK Activation

Journal article
Authors Ryan G. Holzer
Eek-Joong Park
Ning Li
Helen Tran
Monica Chen
Crystal Choi
Giovanni Solinas
Michael Karin
Published in Cell
Volume 147
Issue 1
Pages 173–184
ISSN 0092-8674
Publication year 2011
Published at Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 173–184
Language en
Keywords Lipotoxicity, obesity, insulin resistance, JNK, c-Src
Subject categories Basic Medicine


Saturated fatty acids (FA) exert adverse health effects and are more likely to cause insulin resistance and type 2 diabetes than unsaturated FA, some of which exert protective and beneficial effects. Saturated FA, but not unsaturated FA, activate Jun N-terminal kinase (JNK), which has been linked to obesity and insulin resistance in mice and humans. However, it is unknown how saturated and unsaturated FA are discriminated. We now demonstrate that saturated FA activate JNK and inhibit insulin signaling through c-Src activation. FA alter the membrane distribution of c-Src, causing it to partition into intracellular membrane subdomains, where it likely becomes activated. Conversely, unsaturated FA with known beneficial effects on glucose metabolism prevent c-Src membrane partitioning and activation, which are dependent on its myristoylation, and block JNK activation. Consumption of a diabetogenic high-fat diet causes the partitioning and activation of c-Src within detergent insoluble membrane subdomains of murine adipocytes.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?