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Cerebrospinal fluid analysis for HIV replication and biomarkers of immune activation and neurodegeneration in long-term atazanavir/ritonavir monotherapy treated patients.

Journal article
Authors Francesca Ferretti
Alba Bigoloni
Laura Passeri
Laura Galli
Valeria Longo
Simonetta Gerevini
Vincenzo Spagnuolo
Magnus Gisslén
Henrik Zetterberg
Dietmar Fuchs
Dario Cattaneo
Giada Caramatti
Adriano Lazzarin
Paola Cinque
Antonella Castagna
Published in Medicine
Volume 95
Issue 28
Pages e4144
ISSN 1536-5964
Publication year 2016
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Institute of Biomedicine, Department of Infectious Medicine
Pages e4144
Language en
Links dx.doi.org/10.1097/MD.0000000000004...
Subject categories Neurochemistry

Abstract

Cerebrospinal fluid (CSF) viral escape is a concern in ritonavir-boosted protease inhibitors monotherapy. The aim was to assess HIV-RNA, biomarkers of immune activation and neurodegeneration, and atazanavir concentrations in CSF of patients on successful long-term atazanavir/ritonavir (ATV/r) monotherapy.

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