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Stem cell homing using local delivery of plerixafor and stromal derived growth factor-1alpha for improved bone regeneration around Ti-implants

Journal article
Authors Johan Karlsson
Necati Harmankaya
Anders Palmquist
Saba Atefyekta
Omar Omar
Pentti Tengvall
Martin Andersson
Published in Journal of Biomedical Materials Research. Part A
Volume 104
Issue 10
Pages 2466-2475
ISSN 1549-3296
Publication year 2016
Published at Institute of Clinical Sciences, Section for Anesthesiology, Biomaterials and Orthopaedics, Department of Biomaterials
Pages 2466-2475
Language en
Links dx.doi.org/10.1002/jbm.a.35786
Keywords osseointegration, mesoporous materials, controlled drug delivery, biomedical implants, cell homing
Subject categories Medical Biotechnology

Abstract

Triggering of the early healing events, including the recruitment of progenitor cells, has been suggested to promote bone regeneration. In implantology, local drug release technologies could provide an attractive approach to promote tissue regeneration. In this study, we targeted the chemotactic SDF-1a/CXCR4 axis that is responsible e.g. for the homing of stem cells to trauma sites. This was achieved by local delivery of plerixafor, an antagonist to CXCR4, and/or SDF-1a from titanium implants coated with mesoporous titania thin films with a pore size of 7.5 nm. In vitro drug delivery experiments demonstrated that the mesoporous coating provided a high drug loading capacity and controlled release. The subsequent in vivo study in rat tibia showed beneficial effects with respect to bone-implant anchorage and bone-formation along the surface of the implants when plerixafor and SDF-1a were delivered locally. The effect was most prominent by the finding that the combination of the drugs significantly improved the mechanical bone anchorage. These observations suggest that titanium implants with local delivery of drugs for enhanced local recruitment of progenitor cells have the ability to promote osseointegration. This approach may provide a potential strategy for the development of novel implant treatments.

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