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Review: adiponectin in retinopathy

Journal article
Authors Z. F. Fu
Y. Gong
Chatarina Löfqvist
Ann Hellström
Lois E H Smith
Published in Biochimica Et Biophysica Acta-Molecular Basis of Disease
Volume 1862
Issue 8
Pages 1392-1400
ISSN 0925-4439
Publication year 2016
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
Pages 1392-1400
Language en
Keywords type-2 diabetes-mellitus, oxygen-induced retinopathy, pancreatic, beta-cells, term-equivalent age, macular degeneration, fatty-acids, insulin-resistance, serum adiponectin, mediated improvement, endothelial, function
Subject categories Ophthalmology


Neovascular eye diseases are a major cause of blindness including retinopathy of prematurity, diabetic retinopathy and age-related macular degeneration in which new vessel formation is driven by hypoxia or metabolic abnormalities affecting the fuel supply. White-adipose-tissue derived adipokines such as adiponectin modulate metabolic responses. Increasing evidence shows that lack of adiponectin may result in retinal neovascularization. Activation of the adiponectin pathway may in turn restore energy metabolism, to suppress the drive for compensatory but ultimately pathological neovessels of retinopathy. In this review, we will summarize our current knowledge of the role of adiponectin in eye diseases of premature infants, diabetic patients as well as the elderly. Further investigations in this field are likely to lead to new preventative approaches for these diseases. (C) 2016 Elsevier B.V. All rights reserved.

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