To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Cortical astrogliosis and… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Cortical astrogliosis and increased perivascular aquaporin-4 in idiopathic intracranial hypertension

Journal article
Authors P. K. Eide
V. A. Eidsvaag
E. A. Nagelhus
Hans-Arne Hansson
Published in Brain Research
Volume 1644
Pages 161-175
ISSN 0006-8993
Publication year 2016
Published at Institute of Biomedicine
Pages 161-175
Language en
Keywords Pseudotumor cerebri, Benign intracranial hypertension, Pulsatile intracranial pressure, Astrogliosis, Aquaporin-4, Interstitial fluid disturbance, normal-pressure hydrocephalus, csf opening pressure, body-mass index, pseudotumor cerebri, dark neuron, reference interval, optic-nerve, brain, obesity, benign, Neurosciences & Neurology
Subject categories Neurology


The syndrome idiopathic intracranial hypertension (IIH) includes symptoms and signs of raised intracranial pressure (ICP) and impaired vision, usually in overweight persons. The pathogenesis is unknown. In the present prospective observational study, we characterized the histopathological changes in biopsies from the frontal brain cortical parenchyma obtained from 18 IIH patients. Reference specimens were sampled from 13 patients who underwent brain surgery for epilepsy, tumors or acute vascular diseases. Overnight ICP monitoring revealed abnormal intracranial pressure wave amplitudes in 14/18 IIH patients, who underwent shunt surgery and all responded favorably. A remarkable histopathological observation in IIH patients was patchy astrogliosis defined as clusters of hypertrophic astrocytes enclosing a nest of nerve cells. Distinct astrocyte domains (i.e. no overlap between astrocyte processes) were lacking in most IIH biopsy specimens, in contrast to their prevalence in reference specimens. Evidence of astrogliosis in IIH was accompanied with significantly increased aguaporin-4 (AQP4) immunoreactivity over perivascular astrocytic endfeet, compared to the reference specimens, measured with densitometry. Scattered CD68 immunoreactive cells (activated microglia and macrophages) were recognized, indicative of some inflammation. No apoptotic cells were demonstrable. We conclude that the patchy astrogliosis is a major finding in patients with IIH. We propose that the astrogliosis impairs intracranial pressure-volume reserve capacity, i.e. intracranial compliance, and contributes to the IIH by restricting the outflow of fluid from the cranium. The increased perivascular AQP4 in IIH may represent a compensatory mechanism to enhance brain fluid drainage.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?