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Oxygen Monitoring Reduces the Risk for Retinopathy of Prematurity in a Mexican Population

Journal article
Authors L. C. Zepeda-Romero
Pia Lundgren
J. A. Gutierrez-Padilla
L. M. Gomez-Ruiz
M. Q. Corona
J. V. Orozco-Monroy
A. Barragan-Sanchez
J. C. Razo-Cervantes
Chatarina Löfqvist
Anna-Lena Hård
Ann Hellström
Published in Neonatology
Volume 110
Issue 2
Pages 135-140
ISSN 1661-7800
Publication year 2016
Published at Institute of Neuroscience and Physiology
Pages 135-140
Language en
Keywords Retinopathy of prematurity, Oxygen, Extremely preterm infants, WINROP algorithm, screening algorithm winrop, postnatal weight-gain, preterm infants, gestational-age, birth-weight, prediction, unit, Pediatrics
Subject categories Clinical Medicine


Background: Retinopathy of prematurity (ROP), a potentially blinding disease, affects preterm infants. High levels of oxygen saturation are a well-known risk factor for ROP. Objectives: To assess the frequency of ROP type 1 needing treatment after improved oxygen monitoring (2011) in a Mexican preterm population selected for WINROP analyses and to retrospectively revalidate WINROP, an online surveillance system identifying infants at risk of developing ROP type 1. Methods: Preterm infants born with birth weight (BW) < 1,750 g and/or at gestational age (GA) <= 34 weeks, screened for ROP in 2012-2014 at the Hospital Civil de Guadalajara, Mexico were included (n = 151). Eighty-five infants with GA < 32 weeks qualified for WINROP analyses. GA, BW, maximal ROP stage, ROP treatment and weekly weights were recorded. The results in the present study were compared to those of a previous WINROP study in the same hospital (2005-2010; n = 352). Results: In the present WINROP cohort, 11.8% of the infants born at GA < 32 weeks received treatment compared to 51.0% of the infants in the previous WINROP cohort. One infant (3%) born at GA >= 32 weeks received treatment during the present study period compared to 35.6% during the previous period. WINROP displayed 80.0% sensitivity in infants born at GA < 32 weeks in the present study compared to 84.7% in the previous study. Conclusions: Uncontrolled oxygen supplementation is the major risk factor for severe ROP in infants born at GA >= 32 weeks. After improved oxygen monitoring, the frequency of ROP treatment was dramatically reduced at the Hospital Civil de Guadalajara, Mexico. (C) 2016 S. Karger AG, Basel.

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