To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Gene Therapy Induces Anti… - University of Gothenburg, Sweden Till startsida
Sitemap
To content Read more about how we use cookies on gu.se

Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis

Journal article
Authors Sara Tengvall
Tove Eneljung
Pernilla Jirholt
Olof Turesson
Kajsa Wing
R. Holmdahl
J. Kihlberg
Anna Stern
Inga-Lill Mårtensson
Louise Henningsson
K. Gustafsson
Inger Gjertsson
Published in Plos One
Volume 11
Issue 5
ISSN 1932-6203
Publication year 2016
Published at Institute of Medicine, Department of Rheumatology and Inflammation Research
Language en
Links dx.doi.org/10.1371/journal.pone.015...
Keywords REGULATORY T-CELLS, II COLLAGEN, B-CELLS, AUTOIMMUNE ARTHRITIS, IMMUNE-RESPONSES, DENDRITIC CELLS, TRANSGENIC MICE, SELF-TOLERANCE, INDUCTION, SUPPRESSION
Subject categories Rheumatology and Autoimmunity

Abstract

Here, we investigate induction of immunological tolerance by lentiviral based gene therapy in a mouse model of rheumatoid arthritis, collagen II-induced arthritis (CIA). Targeting the expression of the collagen type II (CII) to antigen presenting cells (APCs) induced antigen-specific tolerance, where only 5% of the mice developed arthritis as compared with 95% of the control mice. In the CII-tolerized mice, the proportion of Tregs as well as mRNA expression of SOCS1 (suppressors of cytokine signaling 1) increased at day 3 after CII immunization. Transfer of B cells or non-B cell APC, as well as T cells, from tolerized to naive mice all mediated a certain degree of tolerance. Thus, sustainable tolerance is established very early during the course of arthritis and is mediated by both B and non-B cells as APCs. This novel approach for inducing tolerance to disease specific antigens can be used for studying tolerance mechanisms, not only in CIA but also in other autoimmune diseases.

Page Manager: Webmaster|Last update: 9/11/2012
Share:

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?