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Polymorphisms of BDNF and CACNA1C are not associated with cognitive functioning in bipolar disorder or healthy controls.

Journal article
Authors Sindre Rolstad
Carl Sellgren Majkowitz
Erik Joas
Carl Johan Ekman
Erik Pålsson
Mikael Landén
Published in Cognitive neuropsychiatry
Volume 21
Issue 3
Pages 271-8
ISSN 1464-0619
Publication year 2016
Published at Institute of Neuroscience and Physiology
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 271-8
Language en
Links dx.doi.org/10.1080/13546805.2016.11...
Subject categories Psychiatry

Abstract

The cause of cognitive dysfunction in bipolar disorder (BD) is not well understood. BDNF and CACNA1C are two susceptibility genes for the disorder that have also been reported to be associated with cognitive deficits in the disorder, but the studies have been small and with conflicting results. We therefore attempted to replicate an association between cognitive dysfunction with the most commonly studied single nucleotide polymorphisms rs6265 and rs1006737.

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