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Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development.

Journal article
Authors Ann Hellström
David Ley
Ingrid Hansen-Pupp
Boubou Hallberg
Chatarina Löfqvist
Linda van Marter
Mirjam van Weissenbruch
Luca A Ramenghi
Kathryn Beardsall
David Dunger
Anna-Lena Hård
Lois E H Smith
Published in Acta paediatrica (Oslo, Norway : 1992)
Volume 105
Issue 6
Pages 576-86
ISSN 1651-2227
Publication year 2016
Published at Institute of Neuroscience and Physiology
Pages 576-86
Language en
Keywords Development; Foetus; Insulin-like growth factor 1; Metabolism; Preterm infant
Subject categories Pediatrics


Poor postnatal growth after preterm birth does not match the normal rapid growth in utero and is associated with preterm morbidities. Insulin-like growth factor 1 (IGF-1) axis is the major hormonal mediator of growth in utero, and levels of IGF-1 are often very low after preterm birth. We reviewed the role of IGF-1 in foetal development and the corresponding preterm perinatal period to highlight the potential clinical importance of IGF-1 deficiency in preterm morbidities.

Page Manager: Webmaster|Last update: 9/11/2012

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