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CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis.

Journal article
Authors Bob Olsson
Ronald Lautner
Ulf Andreasson
Annika Öhrfelt
Erik Portelius
Maria Bjerke
Mikko Hölttä
Christoffer Rosén
Caroline Olsson
Gabrielle Strobel
Elizabeth Wu
Kelly Dakin
Max Petzold
Kaj Blennow
Henrik Zetterberg
Published in The Lancet. Neurology
Volume 15
Issue 7
Pages 673–684
ISSN 1474-4465
Publication year 2016
Published at Institute of Clinical Sciences, Department of Radiation Physics
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Institute of Medicine, Department of Public Health and Community Medicine, Health Metrics
Pages 673–684
Language en
Subject categories Neurochemistry


Alzheimer's disease biomarkers are important for early diagnosis in routine clinical practice and research. Three core CSF biomarkers for the diagnosis of Alzheimer's disease (Aβ42, T-tau, and P-tau) have been assessed in numerous studies, and several other Alzheimer's disease markers are emerging in the literature. However, there have been no comprehensive meta-analyses of their diagnostic performance. We systematically reviewed the literature for 15 biomarkers in both CSF and blood to assess which of these were most altered in Alzheimer's disease.

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