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Risk of intracranial hemorrhage in users of oral antithrombotic drugs: Study protocol for a nationwide study

Journal article
Authors Sasha Gulati
Ole Solheim
Sven M. Carlsen
Lise R. Øie
Heidi Jensberg
Agnete M. Gulati
Charalampis Giannadakis
Asgeir Store Jakola
Øyvind Salvesen
Published in F1000 Research
Volume 4
Pages 1519
Publication year 2015
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Pages 1519
Language en
Links dx.doi.org/10.12688/f1000research.7...
Subject categories Clinical Medicine, Hematology, Neurology, Neurosurgery

Abstract

Background A wide range of antithrombotic medications can be used in the prevention and treatment of thrombosis. Among hemorrhagic complications of antithrombotic drugs, intracranial hemorrhage may have particularly devastating consequences with high morbidity, disability and mortality rates. The incidence and risks of intracranial hemorrhage in patients on antithrombotic treatments from regular clinical practice outside clinical trials remain largely unknown. It is not known if results from clinical trials can be extrapolated to everyday clinical practice. We will conduct a nationwide study to investigate the risks and incidence rates of intracranial hemorrhage in users oral antithrombotic drugs in Norway from 2008 through 2014. Methods and design The aim of this nationwide study is to investigate the incidence rates of intracranial hemorrhage requiring hospitalization in users of oral antithrombotic drugs. The study will be conducted within the approximately 4.7 million inhabitants of Norway from January 1st, 2008, to December 31st, 2014. Treatment and outcome data are obtained from the Norwegian patient registry and the Norwegian prescription database.

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