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Analysis of neuropeptides by MALDI imaging mass spectrometry.

Review article
Authors Anna Ljungdahl
Jörg Hanrieder
Jonas Bergquist
Malin Andersson
Published in Methods in molecular biology (Clifton, N.J.)
Volume 1023
Pages 121-36
ISSN 1940-6029
Publication year 2013
Published at
Pages 121-36
Language en
Keywords Animals, Brain Chemistry, Diagnostic Imaging, methods, Neuropeptides, analysis, Rats, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, methods
Subject categories Basic Medicine, Neurosciences


Matrix-assisted laser desorption ionization (MALDI) imaging mass spectrometry (IMS) is one of the most effective tools for localizing small molecules and compounds directly in thin tissue sections. MALDI IMS should be used when the distribution of molecular species is not known and to localize changes due to a disease process or a treatment. In recent years it has become increasingly clear that many pathological processes are not readily correlated to dramatic changes in protein levels. MALDI IMS can aid the localization of areas where the cellular concentration of proteins may be high enough to play an important biological role, but when the precise location is unknown. Here, we present a MALDI IMS protocol and data analysis of molecular imaging of multiple rat brain sections.

Page Manager: Webmaster|Last update: 9/11/2012

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