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Detection and Phenotypic Characterization of Adult Neurogenesis

Journal article
Authors Hans-Georg Kuhn
A. J. Eisch
K. Spalding
D. A. Peterson
Published in Cold Spring Harbor Perspectives in Biology
Volume 8
Issue 3
ISSN 1943-0264
Publication year 2016
Published at Institute of Neuroscience and Physiology
Language en
Links dx.doi.org/10.1101/cshperspect.a025...
Keywords newly generated neurons, neural stem-cells, hippocampal neurogenesis, dentate gyrus, expression patterns, psa-ncam, intermediate progenitors, doublecortin expression, alzheimers-disease, nervous-system, Cell Biology
Subject categories Cell biology, Neurobiology

Abstract

Studies of adult neurogenesis have greatly expanded in the last decade, largely as a result of improved tools for detecting and quantifying neurogenesis. In this review, we summarize and critically evaluate detection methods for neurogenesis in mammalian and human brain tissue. Besides thymidine analog labeling, cell-cycle markers are discussed, as well as cell stage and lineage commitment markers. Use of these histological tools is critically evaluated in terms of their strengths and limitations, as well as possible artifacts. Finally, we discuss the method of radiocarbon dating for determining cell and tissue turnover in humans.

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