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Loss of the Mediator subunit Med20 affects transcription of tRNA and other non-coding RNA genes in fission yeast

Journal article
Authors Jonas O P Carlsten
Xuefeng Zhu
Marcela Davila Lopez
Tore Samuelsson
Claes M Gustafsson
Published in Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms
Volume 1859
Issue 2
Pages 339-347
ISSN 1874-9399
Publication year 2016
Published at Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Pages 339-347
Language en
Links dx.doi.org/10.1016/j.bbagrm.2015.11...
Keywords Transcription, Mediator, Exosome, tRNA, RNA polymerase III, polymerase-iii transcription, schizosaccharomyces-pombe, quality-control, head module, saccharomyces-cerevisiae, tramp complex, la protein, exosome, polyadenylation, degradation, Biochemistry & Molecular Biology, Biophysics
Subject categories Medical Biotechnology

Abstract

Mediator is a co-regulator of RNA polymerase II (Pol II), transducing signals from regulatory elements and transcription factors to the general transcription machinery at the promoter. We here demonstrate that Med20 influences ribosomal protein expression in fission yeast. In addition, loss of Med20 leads to an accumulation of aberrant, readthrough tRNA transcripts. These transcripts are polyadenylated and targeted for degradation by the exosome. Similarly, other non-coding RNA molecules, such as snRNA, snoRNA and rRNA, are also enriched in the polyadenylate preparations in the absence of Med20. We suggest that fission yeast Mediator takes part in a regulatory pathway that affects Pol III-dependent transcripts.

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