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Control of Cell Survival in Adult Mammalian Neurogenesis

Journal article
Authors Hans-Georg Kuhn
Published in Cold Spring Harbor Perspectives in Biology
Volume 7
Issue 12
ISSN 1943-0264
Publication year 2015
Published at Institute of Neuroscience and Physiology
Language en
Links dx.doi.org/10.1101/cshperspect.a018...
Keywords endothelial growth-factor, newly generated neurons, neural stem-cells, colony-stimulating factor, neurotrophic factor bdnf, rat subventricular, zone, long-term survival, hippocampal neurogenesis, dentate gyrus, olfactory-bulb, Cell Biology
Subject categories Clinical Medicine

Abstract

The fact that continuous proliferation of stem cells and progenitors, as well as the production of new neurons, occurs in the adult mammalian central nervous system (CNS) raises several basic questions concerning the number of neurons required in a particular system. Can we observe continued growth of brain regions that sustain neurogenesis? Or does an elimination mechanism exist to maintain a constant number of cells? If so, are old neurons replaced, or are the new neurons competing for limited network access among each other? What signals support their survival and integration and what factors are responsible for their elimination? This review will address these and other questions regarding regulatory mechanisms that control cell-death and cell-survival mechanisms during neurogenesis in the intact adult mammalian brain.

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