To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Murine Butyrophilin-Like … - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Murine Butyrophilin-Like 1 and BtnI6 Form Heteromeric Complexes in Small Intestinal Epithelial Cells and Promote Proliferation of Local T Lymphocytes

Journal article
Authors Cristina Lebrero-Fernandez
Joakim H. Bergström
Thaher Pelaseyed
Anna Bas-Forsberg
Published in Frontiers in Immunology
Volume 7
Issue 1
ISSN 1664-3224
Publication year 2016
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Language en
Keywords butyrophilin-like, intraepithelial lymphocytes, mucosal immunity, intestinal epithelial cells, gamma, major histocompatibility complex, intraepithelial lymphocytes, interferon-gamma, activation, molecule, btnl2, receptor, stimulation, association, repertoire, Immunology
Subject categories Clinical Medicine


To date, few molecular conduits mediating the cross talk between intestinal epithelial cells and intraepithelial lymphocytes (IELs) have been described. We recently showed that butyrophilin-like (BtnI) 1 can attenuate the epithelial response to activated IELs, resulting in reduced production of proinflammatory mediators, such as IL-6 and CXCL1. We here report that like BtnI1, murine BtnI6 expression is primarily confined to the intestinal epithelium. Although BtnI1 can exist in a cell surface-expressed homomeric form, we found that it additionally forms heteromeric complexes with BtnI6, and that the engagement of BtnI1 is a prerequisite for surface expression of BtnI6 on intestinal epithelial cells. In an IEL-epithelial cell coculture system, enforced epithelial cell expression of BtnI1 significantly enhanced the proliferation of IELs in the absence of exogenous activation. The effect on proliferation was dependent on the presence of IL-2 or IL-15 and restricted to IELs upregulating CD25. In the gamma delta T-cell subset, the BtnI1-BtnI6 complex, but not BtnI1, specifically elevated the proliferation of IELs bearing the V gamma 7V delta 4 receptor. Thus, our results show that murine epithelial cell-specific BtnI proteins can form intrafamily heterocomplexes and suggest that the interaction between BtnI proteins and IELs regulates the expansion of IELs in the intestinal mucosa.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?