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Clinical presentation of infective endocarditis caused by different groups of non-beta haemolytic streptococci.

Journal article
Authors B Nilson
Lars Olaison
M Rasmussen
Published in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Volume 35
Issue 2
Pages 215-218
ISSN 1435-4373
Publication year 2016
Published at Institute of Biomedicine, Department of Infectious Medicine
Pages 215-218
Language en
Links dx.doi.org/10.1007/s10096-015-2532-...
Keywords Infektion, Mikrobiologi, Endokardit
Subject categories Infectious Medicine

Abstract

Streptococci are common causes of infective endocarditis (IE) and matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has provided a practical tool for their species determination. We aimed to investigate if particular groups of non-beta heamolytic streptococci were associated with IE or to specific presentations thereof. The Swedish Registry of Infective Endocarditis was used to identify cases of IE caused by streptococci and a local database to identify cases of streptococcal bacteremia. The bacteria were grouped using MALDI-TOF MS and the clinical characteristics of IE caused by different groups were compared. We identified a group of 201 streptococcal IE isolates: 18 isolates belonged to the anginosus, 19 to the bovis, 140 to the mitis, 17 to the mutans, and seven to the salivarius groups. The mitis and mutans groups were significantly more common and the anginosus group less common among IE cases as compared to all cause bacteremia. Patients infected with the bovis group isolates were older, had more cardiac devices, and had more commonly prosthetic valve IE compared to IE caused by streptococci of the other groups. Twenty-one percent of patients needed surgery, and in-hospital mortality was 8% with no significant differences between the groups. Grouping of non-beta haemolytic streptococci using MALDI-TOF MS can provide a basis for decision-making in streptococcal bacteremia. IE caused by bovis group isolates have clinical characteristics distinguishing them from IE caused by other groups of Streptococcus.

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