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Interaction Of Proteasomes And Complement C3, Assay Of Antisecretory Factor In Blood.

Journal article
Authors Ivar Lönnroth
Merna Oshalim
Stefan Lange
Ewa Johansson
Published in Journal of immunoassay & immunochemistry
Volume 37
Issue 1
Pages 43-54
ISSN 1532-1819
Publication year 2016
Published at Institute of Biomedicine, Department of Infectious Medicine
Pages 43-54
Language en
Keywords Keywords antisecretory factor, circulating proteasomes, complement, cereals, inflammation
Subject categories Immunobiology, Infectious Medicine, Clinical Laboratory Medicine


Antisecretory factor (AF) is a protein complex which inhibits inflammation and regulates fluid transport. In the present study two new immunoassays (ELISA) are developed. The first ELISA establishing a 26S proteasome concentration of 0.41±0.03 µg/ml in normal plasma, the second ELISA disclosing the binding of proteasomes to complement factor C3. The latter test values increased about tenfold following intake of processed cereals, paralleling with the old AF ELISA. The proteasome/C3 complex is purified and shown to expose hidden antisecretory peptide sequence and contain the inactive C3c protein. These findings might explain the antisecretory and anti-inflammatory effect during AF complex formation.

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