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Alterations in Tumor DNA Are Related to Short Postoperative Survival in Patients Resected for Pancreatic Carcinoma Aimed at Cure.

Journal article
Authors Annika Gustafsson Asting
David Ljungman
Helena Carén
Zilvinas Dambrauskas
Britt-Marie Iresjö
Anders Hyltander
Peter Naredi
Kent Lundholm
Published in Pancreas
Volume 45
Issue 6
Pages 900-907
ISSN 1536-4828
Publication year 2016
Published at Institute of Clinical Sciences, Department of Surgery
Sahlgrenska Cancer Center
Institute of Biomedicine, Department of Pathology
Pages 900-907
Language en
Links dx.doi.org/10.1097/MPA.000000000000...
Keywords pancreatic cancer; CGH arrays; DNA methylation; KRAS mutation; survival; CNV
Subject categories Cancer and Oncology, Surgery

Abstract

Pancreatic ductal adenocarcinomas (PDACs) are found in more than 85% of patients with pancreatic cancer and with 5-year survival of less than 10%. Effective treatment may be radical surgery, which is hampered by rapid relapse. Therefore, our aim was to compare DNA sequence alterations in patients with short and long survival to evaluate if confirmed DNA alterations predict short postoperative survival.

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