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Food-related gastrointestinal symptoms, nutrient intake and dietary interventions in patients with irritable bowel syndrome

Doctoral thesis
Authors Lena Böhn
Date of public defense 2015-01-30
ISBN 978-91-628-9245-6
Publication year 2015
Published at Institute of Medicine
Language en
Keywords irritable bowel syndrome, gastrointestinal symptoms, diet
Subject categories Internal medicine


Food is a recurrent problem in irritable bowel syndrome (IBS) and it is common to exclude foods, which could lead to a reduced nutrient intake. Perceived food intolerance is very common in IBS, but if specific or more generalized food intolerance is the problem is unknown. Incompletely absorbed carbohydrates (fermentable oligo-, di-, mono-saccharides and polyols, FODMAPs) can trigger gastrointestinal (GI) symptoms, but if an enzyme (α-galactosidase), capable of digesting oligosaccharides, is able to relieve meal-related symptoms, or if a diet low in FODMAPs is more efficient in reducing symptoms than traditional dietary advice is not known. Methods: Paper 1: The nutrient intake (from food diaries) in IBS patients was compared with a sex-and-age matched population from a Swedish national dietary survey. Paper 2: IBS patients completed questionnaires to assess self-reported food intolerance and the association with other clinical and demographic variables. Paper 3: In a randomized, double-blind, placebo-controlled, crossover trial; the effect of α-galactosidase on GI symptoms in IBS patients after carbohydrate-rich meals was investigated. Paper 4: In a randomized, single-blind, parallel group, four-week trial; the effect on IBS symptoms of a low FODMAPs diet was compared with traditional dietary advice in IBS. Main results: The nutrient intake in IBS patients was similar to the Swedish general population. Eighty-four percent of IBS patients reported food-related GI symptoms, especially after intake of foods rich in incompletely absorbed carbohydrates and fat. Self-reported food intolerance was associated with more severe IBS symptoms and reduced quality of life. α-galactosidase was not superior to placebo in reducing GI symptoms after carbohydrate-rich meals in IBS patients. Fifty percent in the low FODMAPs group responded favorably to the dietary intervention (reduced GI symptoms), and 46 % were responders in the group who received traditional dietary advice. Conclusions: Despite a high degree of self-reported food intolerance in IBS, the majority of these patients seem to have adequate nutrient intake. A low FODMAPs diet and traditional IBS dietary advice, but not α-galactosidase capsules, reduce symptom burden in patients with IBS.

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