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Polymorphisms of dopamine pathway genes NRG1 and LMX1A are associated with cognitive performance in bipolar disorder

Journal article
Authors Sindre Rolstad
Erik Pålsson
Carl Johan Ekman
Elias Eriksson
Carl Sellgren
Mikael Landén
Published in Bipolar disorders
Volume 17
Issue 8
Pages 859–868
ISSN 1399-5618
Publication year 2015
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Institute of Neuroscience and Physiology, Department of Pharmacology
Pages 859–868
Language en
Links dx.doi.org/10.1111/bdi.12347
Keywords NRG1, LMX1A, bipolar disorder
Subject categories Pharmacology

Abstract

LIM homeobox transcription factor 1, alpha (LMX1A) and neuregulin 1 (NRG1) are susceptibility genes for schizophrenia that have been implicated in the dopaminergic pathway and have been associated with altered cognitive functioning. We hypothesized that single nucleotide polymorphisms (SNPs) in LMX1A and NRG1 would be associated with cognitive functioning in bipolar disorder.

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