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High recovery rate of non-albicans Candida species isolated from burn patients with candidemia in Iran

Journal article
Authors N. Lotfi
T. Shokohi
S. Z. Nouranibaladezaei
A. N. Omran
Nahid Kondori
Published in Jundishapur Journal of Microbiology
Volume 8
Issue 10
ISSN 2008-3645
Publication year 2015
Published at Institute of Biomedicine, Department of Infectious Medicine
Language en
Links dx.doi.org/10.5812/jjm.22929
Keywords Burn Patients, Burns, Candida, Candidemia, Diagnosis, In vitro Antifungal Susceptibility, Iran, Non-albicans Candida
Subject categories Infectious Medicine

Abstract

Background: Blood stream infections (BSIs) are major causes of morbidity and mortality in burn patients. Microorganisms responsible for BSI are generally bacteria; however, Candida spp. are the infection agents in as many as 8% of all cases. Burn wound colonization and infections are generally the first steps to systemic infection. Candidemia in burn patients has been associated with high mortality and a prolonged hospital stay. Objectives: Candidemia in burn patients has been defined as a preterminal event, leading to high morbidity and mortality rates among these patients. The aim of this study was to establish the incidence of candidemia in burn patients in Iran. Patients and Methods: We consecutively collected 405 blood samples from 113 burn patients. The yeast isolates were identified to the species level using conventional procedures. In vitro antifungal susceptibility of the Candida isolates to amphotericin B, fluconazole, voriconazole and caspofungin was performed using the Etest. Results: Twenty-seven samples (6.7%) of the blood cultures from 13 patients (12%) were positive for Candida species. Candida parapsilosis (38%) and C. tropicalis (38%) were the most commonly found Candida species, followed by C. albicans (15%) and C. guilliermondii (15%) in the patients. The incidence of candidemia was significantly correlated with increased duration of hospitalization, increased time of stay in the intensive care unit, and higher mortality. The antifungal susceptibility tests demonstrated that amphotericin B and voriconazole had the lowest minimum inhibitory concentrations (MICs) against Candida spp. Conclusions: Non-albicans Candida should be considered as significant pathogens in burned patients with candidemia. © 2015, Ahvaz Jundishapur University of Medical Sciences.

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