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Helicobacter pylori Infection of the Gastric Mucosa

Chapter in book
Authors Sukanya Raghavan
Jan Holmgren
Ann-Mari Svennerholm
Published in Mucosal Immunology: Fourth Edition
Volume 1-2
Pages 985-1001
ISBN 978-0-12-415847-4
Publisher Elsevier
Publication year 2015
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Pages 985-1001
Language en
Keywords CD4+ T cells, Gastritis, Helicobacter pylori, IgA, Regulatory T cells, Vaccines
Subject categories Immunology in the medical area


Half of the world's population is infected with Helicobacter pylori, one of the few microorganisms known to colonize the human stomach and persist for decades. Chronic infection with H. pylori is the main cause of peptic ulcers and of gastric cancer in 1-2% of infected individuals. In infected individuals, activation of the innate and adaptive immune systems leads to recruitment of a wide range of inflammatory cell types, including granulocytes and lymphocytes, to the stomach. Although vigorous mucosal and systemic immune responses to the infection are generated, H. pylori is rarely spontaneously eradicated. In countries where H. pylori is endemic, reinfections, accompanied by the return of peptic ulcer disease, often occur after treatment. Owing to the high prevalence of infection and the risk for reinfection, vaccination of symptomatic patients would be the most cost-effective way to control H. pylori-induced ulcer disease and gastric cancer on a global scale. © 2015 Elsevier Inc. All rights reserved.

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