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Neutrophil NET formation is regulated from the inside by myeloperoxidase-processed reactive oxygen species.

Journal article
Authors Halla Björnsdottir
Amanda Welin
Erik Michaëlsson
Veronica Osla
Stefan Berg
Karin Christenson
Martina Sundqvist
Claes Dahlgren
Anna Karlsson
Johan Bylund
Published in Free radical biology & medicine
Volume 89
Pages 1024-1035
ISSN 1873-4596
Publication year 2015
Published at Institute of Odontology
Institute of Medicine, Department of Rheumatology and Inflammation Research
Pages 1024-1035
Language en
Links dx.doi.org/10.1016/j.freeradbiomed....
Subject categories Pediatrics

Abstract

Neutrophil extracellular traps (NETs) are mesh-like DNA fibers clad with intracellular proteins that are cast out from neutrophils in response to certain stimuli. The process is thought to depend on reactive oxygen species (ROS) generated by the phagocyte NADPH-oxidase and the ROS-modulating granule enzyme myeloperoxidase (MPO), but when, how, and where these factors contribute is so far uncertain. The neutrophil NADPH-oxidase can be activated at different cellular sites and ROS may be produced and processed by MPO within intracellular granules, even in situations where a phagosome is not formed, e.g., upon stimulation with phorbol myristate acetate (PMA).

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