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Inflammation, Immunity, and Vaccines for Helicobacter pylori Infection

Review article
Authors A. Walduck
L. P. Andersen
Sukanya Raghavan
Published in Helicobacter
Volume 20
Issue Supplement: 1 Special Issue: SI
Pages 17-25
ISSN 1083-4389
Publication year 2015
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Pages 17-25
Language en
Links dx.doi.org/10.1111/hel.12252
Keywords Helicobacter pylori, inflammation, IL-23 and vaccines, SECONDARY LYMPHOID FOLLICLES, DENDRITIC CELLS, GASTRIC-CANCER, BALB/C, MICE, NEONATAL THYMECTOMY, EPITHELIAL-CELLS, CTB-UE, MUCOSA, POLYMORPHISMS, PEPTIDOGLYCAN, Gastroenterology & Hepatology, Microbiology
Subject categories Microbiology in the medical area, Gastroenterology and Hepatology

Abstract

During the last year, a variety of studies have been published that increases our understanding of the basic mechanisms of immunity and inflammation in Helicobacter pylori infection and progression to gastric cancer. Innate immune regulation and epithelial cell response were covered by several studies that contribute with new insights in the host response to H. pylori infection. Also, the adaptive immune response to H. pylori and particularly the role of IL-22 have been addressed in some studies. These advances may improve vaccine development where new strategies have been published. Two major studies analyzed H. pylori genomes of 39 worldwide strains and looked at the protein profiles. In addition, multi-epitope vaccines for therapeutic use have been investigated. Studies on different adjuvants and delivery systems have also given us new insights. This review presents articles from the last year that reveal detailed insight into immunity and regulation of inflammation, the contribution of immune cells to the development of gastric cancer, and understanding mechanisms of vaccine-induced protection.

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