To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Salivary mucin MUC7 oligo… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Salivary mucin MUC7 oligosaccharides in patients with recurrent aphthous stomatitis

Journal article
Authors Mikael Zad
Sarah A. Flowers
Maria Bankvall
Mats Jontell
Niclas G. Karlsson
Published in Clinical Oral Investigations
Volume 19
Issue 8
Pages 2147-2152
ISSN 1432-6981
Publication year 2015
Published at Institute of Odontology, Section 1
Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Pages 2147-2152
Language en
Keywords Oral mucosa, Mucin layer, Glycan, Saliva, Aphthous ulcers, BLOOD-GROUP, GLYCOSYLATION, GLYCANS
Subject categories Dentistry


Objectives The aetiology of recurrent aphthous stomatitis remains unknown. In this study, we investigate the composition of oligosaccharides from mucin MUC7 in recurrent aphthous stomatitis as these heavily O-glycosylated mucins confer many of saliva's protective properties such as defence against mucosal pathogens. Materials and methods Unstimulated whole saliva samples were collected from six individuals, three with recurrent aphthous stomatitis and three corresponding sibling, without this condition. Oligosaccharides from salivary MUC7 were isolated and analysed by liquid chromatography-tandem mass spectrometry. Results The types of oligosaccharides identified in the patients and control subjects were similar; however, statistical evaluation indicated semi-quantitative differences between specific oligosaccharide classes. These changes focused on a reduction in terminal glycan residues including fucosylation, sialylation and sulfation on galactose. Conclusions This study was able to show differential MUC7 glycosylation in the patients suggesting functional changes to salivary mucins in this condition. The terminal glycans altered in disease have been shown to be important for a range of immunological and bacterial binding roles. Further investigation of these epitopes in a larger study may provide critical insights into the pathology of recurrent aphthous stomatitis. Clinical relevance MUC7 glycosylation is altered in recurrent aphthous stomatitis. This may change the protective properties of this mucin against mucosal pathogens, which may effect this condition.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?