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CACNA1C polymorphism and altered phosphorylation of tau in bipolar disorder.

Journal article
Authors Joel Jakobsson
Erik Pålsson
Carl Sellgren
Frida Rydberg
Agneta Ekman
Henrik Zetterberg
Kaj Blennow
Mikael Landén
Published in The British journal of psychiatry : the journal of mental science
Volume 208
Issue 2
Pages 195-196
ISSN 1472-1465
Publication year 2016
Published at Institute of Neuroscience and Physiology
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Institute of Neuroscience and Physiology, Department of Pharmacology
Pages 195-196
Language en
Links dx.doi.org/10.1192/bjp.bp.114.15980...
Subject categories Neurochemistry

Abstract

Several genome-wide association studies and case-control studies have associated the single nucleotide polymorphism (SNP) rs1006737, situated in CACNA1C encoding the alpha 1C subunit of the L-type voltage-gated calcium channel, with bipolar disorder and other psychiatric disorders. However, the causal pathway linking genetic variants in CACNA1C with increased risk for developing brain disorders remains unclear. Here, we explored the association between the rs1006737 SNP and cerebrospinal fluid (CSF) markers. We found a significant association between the risk allele in rs1006737 and a decreased CSF hyperphosphorylated tau/total tau ratio in patients with bipolar disorder, thus linking variation in the CACNA1C gene to a neurochemical marker of neuroaxonal plasticity in those with this disorder.

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