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Role of noroviruses as aetiological agents of diarrhoea in developing countries

Journal article
Authors James Ayukekbong
H. N. Mesumbe
O. G. Oyero
Magnus Lindh
Tomas Bergström
Published in Journal of General Virology
Volume 96
Pages 1983-1999
ISSN 0022-1317
Publication year 2015
Published at Institute of Biomedicine, Department of Infectious Medicine
Pages 1983-1999
Language en
Keywords blood group antigens, norwalk-like viruses, infectious nonbacterial, gastroenteritis, winter vomiting disease, treated waste-water, linked-immunosorbent-assay, acute childhood diarrhea, round structured, virus, human enteric viruses, united-states, Biotechnology & Applied Microbiology, Virology
Subject categories Infectious Medicine


Diarrhoea is considered to be the second leading cause of death due to infections among children <5 years of age worldwide that may be caused by bacteria, parasites, viruses and non-infectious agents. The major causative agents of diarrhoea in developing countries may vary from those in developed countries. Noroviruses are considered to be the most common cause of acute diarrhoea in both children and adults in industrialized countries. On the other hand, there is a lack of comprehensive epidemiological evidence from developing countries that norovirus is a major cause of diarrhoea. In these regions, asymptomatic norovirus infections are very common, and similar detection rates have been observed in patients with diarrhoea and asymptomatic persons. This review summarizes the current knowledge of norovirus infection in developing countries and seeks to position infections with noroviruses among those of other enteropathogens in terms of disease burden in these regions.

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