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Staphylococcus epidermidis Bacteremia Induces Brain Injury in Neonatal Mice via Toll-like Receptor 2-Dependent and -Independent Pathways

Journal article
Authors Dan Bi
Lili Qiao
Ilana Bergelson
C. Joakim Ek
Luqi Duan
Xiaoli Zhang
Anna-Maj Albertsson
Matthew Pettengill
Kenny Kronforst
Jana Ninkovic
Donald Goldmann
Anders Janzon
Henrik Hagberg
Xiaoyang Wang
Carina Mallard
Ofer Levy
Published in The Journal of infectious diseases
Volume 212
Issue 9
Pages 1480-90
ISSN 1537-6613
Publication year 2015
Published at Institute of Neuroscience and Physiology
Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Institute of Neuroscience and Physiology, Department of Physiology
Institute of Clinical Sciences, Department of Obstetrics and Gynecology
Pages 1480-90
Language en
Subject categories Neurology


Staphylococcus epidermidis causes late-onset sepsis in preterm infants. Staphylococcus epidermidis activates host responses in part via Toll-like receptor 2 (TLR2). Epidemiologic studies link bacteremia and neonatal brain injury, but direct evidence is lacking.

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