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Age-contingent influence over accumbal neurotransmission and the locomotor stimulatory response to acute and repeated administration of nicotine in Wistar rats

Journal article
Authors Louise Adermark
Julia Morud
Amir Lotfi
Susanne Jonsson
Bo Söderpalm
Mia Ericson
Published in Neuropharmacology
Volume 97
Pages 104-112
ISSN 0028-3908
Publication year 2015
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 104-112
Language en
Links dx.doi.org/10.1016/j.neuropharm.201...
Keywords Behavioral sensitization, Dopamine, Electrophysiology, Nucleus accumbens, Microdialysis, VENTRAL TEGMENTAL AREA, SOMATODENDRITIC DOPAMINE RELEASE, ACETYLCHOLINE-RECEPTOR BLOCKADE, CONDITIONED PLACE PREFERENCE, LONG-LASTING DISINHIBITION, FREELY MOVING RATS, ELEVATED PLUS-MAZE, NUCLEUS-ACCUMBENS, CHOLINERGIC INTERNEURONS, CROSS-SENSITIZATION, Neurosciences, Pharmacology & Pharmacy
Subject categories Neurosciences, Pharmacology and Toxicology

Abstract

Nicotine addiction is one of the leading contributors to the global burden of disease, and early onset smokers report a more severe addiction with lower chance of cessation than those with a late onset. Preclinical research supports an age-dependent component to the rewarding and reinforcing properties of nicotine, and the aim of this study was to. define behavioral adaptations and changes in accumbal neurotransmission that arise over 15 days of intermittent nicotine treatment (0.36 mg/kg/day) in rats of three different ages (5 weeks, 10 weeks, 36 weeks old). Repeated treatment increased the locomotor stimulatory response to nicotine in all age groups, but significantly faster in the two younger groups. In addition, nicotine decreased rearing activity in a way that sustained even after repeated administration in aged rats but not in the younger age groups. Electrophysiological field potential recordings revealed a decline in input/output function in the nucleus accumbens (NAc) of animals intermittently treated with nicotine starting at 5 weeks of age, but not in older animals. In drug naive rats, acute administration of nicotine modulated both accumbal dopamine output and excitatory transmission in a partially age dependent manner. Fifteen days of intermittent nicotine treatment did not alter the acute effect displayed by nicotine on dopamine levels or evoked field potentials. The data presented here show that both acute and repeated nicotine administration modulates accumbal neurotransmission and behavior in an age-contingent manner and that these age-dependent differences could reflect important neurobiological underpinnings associated with the increased vulnerability for nicotine-addiction in adolescents. (C) 2015 Elsevier Ltd. All rights reserved.

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