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α-Imaging Confirmed Efficient Targeting of CD45-Positive Cells After 211At-Radioimmunotherapy for Hematopoietic Cell Transplantation.

Journal article
Authors Sofia Frost
Brian W Miller
Tom Bäck
Erlinda B Santos
Donald K Hamlin
Sue E Knoblaugh
Shani L Frayo
Aimee L Kenoyer
Rainer Storb
Oliver W Press
D Scott Wilbur
John M Pagel
Brenda M Sandmaier
Published in Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Volume 56
Issue 11
Pages 1766-1773
ISSN 1535-5667
Publication year 2015
Published at Institute of Clinical Sciences, Department of Radiation Physics
Pages 1766-1773
Language en
Links dx.doi.org/10.2967/jnumed.115.16238...
Subject categories Radiological physics

Abstract

Alpha-radioimmunotherapy targeting CD45 may substitute for total body irradiation in hematopoietic cell transplantation (HCT) preparative regimens for lymphoma. Our goal was to optimize the anti-CD45 monoclonal antibody (MAb; CA12.10C12) protein dose for astatine-211 ((211)At)-radioimmunotherapy, extending the analysis to include intra-organ (211)At activity distribution and α-imaging-based small-scale dosimetry, along with immunohistochemical staining.

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