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Apolipoprotein E polymorphism in aneurysmal subarachnoid haemorrhage in West Sweden.

Journal article
Authors Ludvig Z Csajbok
Karin Nylén
Martin Öst
Kaj Blennow
Henrik Zetterberg
Per Nellgård
Bengt Nellgård
Published in Acta neurologica Scandinavica
Volume 133
Issue 6
Pages 466–474
ISSN 1600-0404
Publication year 2016
Published at Institute of Neuroscience and Physiology
Institute of Clinical Sciences, Department of Anesthesiology and Intensive care
Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Pages 466–474
Language en
Links dx.doi.org/10.1111/ane.12487
Subject categories Anesthesiology and Intensive Care

Abstract

Aneurysmal subarachnoid haemorrhage (aSAH) is associated with high morbidity and mortality despite novel treatments. Genetic variability may explain outcome differences. Apolipoprotein E (ApoE) is a glycoprotein with a major role in brain lipoprotein metabolism. It has three isoforms encoded by distinct alleles: APOEε2, APOEε3 and APOEε4. The APOEε4 allele is associated with Alzheimer's disease and worse outcome after traumatic brain injury and ischaemic stroke. This prospective blinded study explored the influence of the APOEε4 polymorphism on the risk of aSAH, risk of cerebral vasospasm (CVS) and 1-year neurological outcome.

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