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Potential Biomarkers for Radiation-Induced Renal Toxicity following 177Lu-Octreotate Administration in Mice.

Journal article
Authors Emil Schüler
Maria Larsson
Toshima Z Parris
Martin E Johansson
Khalil Helou
Eva Forssell-Aronsson
Published in PloS one
Volume 10
Issue 8
Pages e0136204
ISSN 1932-6203
Publication year 2015
Published at Institute of Clinical Sciences, Department of Radiation Physics
Institute of Clinical Sciences, Department of Oncology
Sahlgrenska Cancer Center
Pages e0136204
Language en
Links dx.doi.org/10.1371/journal.pone.013...
Subject categories Cancer and Oncology

Abstract

C57BL/6N mice were i.v. injected with 0, 30, 60, 90, 120, or 150 MBq 177Lu-octreotate (0, 16, 29, 40, 48, and 54 Gy to the kidneys). At 4, 8, and 12 months after administration, radiation-induced effects were evaluated in relation to (a) global transcriptional variations in kidney tissues, (b) morphological changes in the kidneys, (c) changes in white and red blood cell count as well as blood levels of urea, and (d) changes in renal function using 99mTc-DTPA/99mTc-DMSA scintigraphy.

Page Manager: Webmaster|Last update: 9/11/2012
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