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Transcriptional profiling of breast cancer metastases identifies liver metastasis-selective genes associated with adverse outcome in luminal A primary breast cancer.

Journal article
Authors Siker Kimbung
Ida Johansson
Anna Danielsson
Srinivas Veerla
Suzanne Egyhazi Brage
Marianne Frostvik Stolt
Lambert Skoog
Lena Carlsson
Zakaria Einbeigi
Elisabet Lidbrink
Barbro Linderholm
Niklas Loman
Per Malmström
Martin Söderberg
Thomas M Walz
Mårten Fernö
Thomas Hatschek
Ingrid A Hedenfalk
Published in Clinical cancer research : an official journal of the American Association for Cancer Research
Volume 22
Issue 146
ISSN 1078-0432
Publication year 2016
Published at Institute of Clinical Sciences, Department of Oncology
Language en
Links dx.doi.org/10.1158/1078-0432.CCR-15...
Subject categories Cancer and Oncology

Abstract

The complete molecular basis of the organ-specificity of metastasis is elusive. This study aimed to provide an independent characterization of the transcriptional landscape of breast cancer metastases with the specific objective to identify liver metastasis-selective genes of prognostic importance following primary tumor diagnosis.

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