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Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation

Journal article
Authors Valentina Tremaroli
Fredrik H. Karlsson
Malin Werling
Marcus Ståhlman
Petia Kovatcheva-Datchary
Torsten Olbers
Lars Fändriks
Carel W le Roux
Jens B. Nielsen
Fredrik Bäckhed
Published in Cell Metabolism
Volume 22
Issue 2
Pages 228-238
ISSN 1550-4131
Publication year 2015
Published at Wallenberg Laboratory
Institute of Clinical Sciences, Department of Gastrosurgical Research and Education
Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 228-238
Language en
Links dx.doi.org/10.1016/j.cmet.2015.07.0...
https://gup.ub.gu.se/file/184810
Subject categories Gastroenterology and Hepatology

Abstract

Bariatric surgery is currently the most effective procedure for the treatment of obesity. Given the role of the gut microbiota in regulating host metabolism and adiposity, we investigated the long-term effects of bariatric surgery on the microbiome of patients randomized to Roux-en-Y gastric bypass or vertical banded gastroplasty and matched for weight and fat mass loss. The two surgical procedures induced similar and durable changes on the gut microbiome that were not dependent on body mass index and resulted in altered levels of fecal and circulating metabolites compared with obese controls. By colonizing germ-free mice with stools from the patients, we demonstrated that the surgically altered microbiota promoted reduced fat deposition in recipient mice. These mice also had a lower respiratory quotient, indicating decreased utilization of carbohydrates as fuel. Our results suggest that the gut microbiota may play a direct role in the reduction of adiposity observed after bariatric surgery.

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