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Cognitive Performance and Cerebrospinal Fluid Biomarkers of Neurodegeneration: A Study of Patients with Bipolar Disorder and Healthy Controls

Journal article
Authors Sindre Rolstad
Joel Jakobsson
C. Sellgren
C. J. Ekman
Kaj Blennow
Henrik Zetterberg
Erik Pålsson
Mikael Landén
Published in Plos One
Volume 10
Issue 5
Pages e0127100
ISSN 1932-6203
Publication year 2015
Published at Institute of Neuroscience and Physiology
Pages e0127100
Language en
Links dx.doi.org/10.1371/journal.pone.012...
Keywords AMYLOID PRECURSOR PROTEIN, ALZHEIMER-DISEASE, 1ST-DEGREE RELATIVES, IN-VIVO, METAANALYSIS, IMPAIRMENT, A-BETA(42), SCHIZOPHRENIA, NEUROTOXICITY, IMPACT, Multidisciplinary Sciences
Subject categories Neurosciences

Abstract

The purpose of the present study was to investigate if cerebrospinal fluid (CSF) biomarkers of neurodegeneration are associated with cognition in bipolar disorder and healthy controls, respectively. CSF concentrations of total and phosphorylated tau, amyloid beta (A beta) 1-42, ratios of A beta 42/40 and A beta 42/38, soluble amyloid precursor protein alpha and beta, and neurofilament light chain protein were analyzed in relation to neuropsychological performance in 82 euthymic bipolar disorder patients and 71 healthy controls. Linear regression models were applied to account for performance in five cognitive domains using the CSF biomarkers. In patients, the CSF biomarkers explained a significant proportion of the variance (15-36%, p =. 002 -<. 0005) in all cognitive domains independently of age, medication, disease status, and bipolar subtype I or II. However, the CSF biomarkers specifically mirroring Alzheimer-type brain changes, i.e., P-tau and A beta 1-42, did not contribute significantly. In healthy controls, CSF biomarkers did not explain the variance in cognitive performance. Selected CSF biomarkers of neurodegenerative processes accounted for cognitive performance in persons with bipolar disorder, but not for healthy controls. Specifically, the ratios of A beta 42/40 and A beta 42/38 were consistently associated with altered cognitive performance.

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