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Antimicrobial Effect of a Single Dose of Amoxicillin on the Oral Microbiota.

Journal article
Authors Cecilia Larsson Wexell
Henrik Ryberg
Wivi-Anne Sjöberg Andersson
Susanne Blomqvist
Pieter Colin
Jan Van Bocxlaer
Gunnar Dahlén
Published in Clinical implant dentistry and related research
Volume 18
Issue 6
Pages 609-706
ISSN 1708-8208
Publication year 2016
Published at Institute of Odontology
Institute of Clinical Sciences, Department of Biomaterials
Centre for Bone and Arthritis Research
Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Institute of Odontology, Section 3
Pages 609-706
Language en
Keywords amoxicillin;LC-MS/MS;oral microbiology;oral surgery;plasma;saliva
Subject categories Biomaterials


Amoxicillin is commonly used in oral surgery for antimicrobial prophylaxis against surgical-site infection and bacteremia because of its effect on oral streptococci. The aim of this study was to determine whether amoxicillin reaches the break-point concentrations in saliva and has any effect on the salivary microbiota, colonizing bacteria on mucosal membranes and on the gingival crevice after a single dose of amoxicillin.

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