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Rip2 modifies VEGF-induced signalling and vascular permeability in myocardial ischemia

Journal article
Authors Linda Andersson
Margareta Scharin Täng
Annika Lundqvist
Malin Lindbom
Ismena Mardani
Per Fogelstrand
Puja Shahrouki
Björn Redfors
Elmir Omerovic
Max Levin
Jan Borén
Malin Levin
Published in Cardiovascular Research
Volume 107
Issue 4
Pages 478-486
ISSN 0008-6363
Publication year 2015
Published at Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 478-486
Language en
Links dx.doi.org/10.1093/cvr/cvv186
Subject categories Cardiovascular medicine

Abstract

In myocardial ischemia, vascular endothelial growth factor (VEGF) induces permeability by activating a signalling pathway that includes VEGF receptor 2 (VEGFR2), resulting in increased oedema and inflammation and thereby expanding the area of tissue damage. In this study, we investigated the role of receptor-interacting protein 2 (Rip2) in VEGF signalling and myocardial ischemia/reperfusion injury.

Page Manager: Webmaster|Last update: 9/11/2012
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