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CSF neuroinflammatory biomarkers in bipolar disorder are associated with cognitive impairment.

Journal article
Authors Sindre Rolstad
Joel Jakobsson
Carl Sellgren
Anniella Isgren
Carl Johan Ekman
Maria Bjerke
Kaj Blennow
Henrik Zetterberg
Erik Pålsson
Mikael Landén
Published in European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Volume 25
Issue 8
Pages 1091–1098
ISSN 1873-7862
Publication year 2015
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 1091–1098
Language en
Links dx.doi.org/10.1016/j.euroneuro.2015...
Keywords Bipolar disorder; Cerebrospinal fluid; Inflammation; Neuropsychology
Subject categories Basic Medicine

Abstract

Persistent cognitive impairment in the euthymic state of bipolar disorder is increasingly recognized. Mounting evidence also suggests an association between neuroinflammation and cognitive dysfunction. The purpose of this study was to test if cerebrospinal fluid (CSF) markers of neuroinflammation could account for cognitive impairment in bipolar disorder. Hierarchical linear regression models were applied to account for performance in five cognitive domains using CSF neuroinflammatory biomarkers as predictors in patients with bipolar disorder type I and II (N=78). The associations between these biomarkers and cognition were further tested in healthy age- and sex-matched controls (N=86). In patients with bipolar disorder, the CSF biomarkers accounted for a significant proportion of the variance in executive functions (42.8%, p=<.0005) independently of age, medication, disease status, and bipolar subtype. The microglial marker YKL-40 had a high impact (beta=-.99), and was the only biomarker that contributed individually. CSF biomarkers were not associated with cognitive performance in healthy controls. The CSF neuroinflammation biomarker YKL-40 is associated with executive performance in euthymic bipolar disorder, but not in healthy controls.

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