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Inflammatory Cytokines and Biomarkers of Cartilage Metabolism 8 Years After Anterior Cruciate Ligament Reconstruction: Results From Operated and Contralateral Knees.

Journal article
Authors Martina Åhlén
Leyla Roshani
Mattias Lidén
André Struglics
Lars Rostgård-Christensen
Jüri Kartus
Published in The American journal of sports medicine
Volume 43
Issue 6
Pages 1460-1466
ISSN 1552-3365
Publication year 2015
Published at Institute of Clinical Sciences, Department of Orthopaedics
Pages 1460-1466
Language en
Subject categories Orthopedics


Patients who sustain an acute anterior cruciate ligament (ACL) rupture are at increased risk to develop posttraumatic arthritis (PTA) in the injured knee whether the ACL is reconstructed or treated nonoperatively. Inflammatory cytokines and cartilage degradation biomarkers are elevated at the time of acute injury and postoperatively. This suggests that one mechanism for PTA may be an inflammatory degradative process initiated on the acute injury and sustained for some length of time independent of whether adequate joint stability is restored.

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