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Explorative and targeted neuroproteomics in Alzheimer's disease.

Journal article
Authors Ann Brinkmalm-Westman
Erik Portelius
Annika Öhrfelt
Gunnar Brinkmalm
Ulf Andreasson
Johan Gobom
Kaj Blennow
Henrik Zetterberg
Published in Biochimica et biophysica acta
Volume 1854
Issue 7
Pages 769–778
ISSN 0006-3002
Publication year 2015
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 769–778
Language en
Links dx.doi.org/10.1016/j.bbapap.2015.01...
Keywords Alzheimer's disease; Neuroproteomic
Subject categories Neurochemistry

Abstract

Alzheimer's disease (AD) is a progressive brain amyloidosis that injures brain regions involved in memory consolidation and other higher brain functions. Neuropathologically, the disease is characterized by accumulation of a 42 amino acid peptide called amyloid β (Aβ42) in extracellular senile plaques, intraneuronal inclusions of hyperphosphorylated tau protein in neurofibrillary tangles, and neuronal and axonal degeneration and loss. Biomarker assays capturing these pathologies have been developed for use on cerebrospinal fluid samples but there are additional molecular pathways that most likely contribute to the neurodegeneration and full clinical expression of AD. One way of learning more about AD pathogenesis is to identify novel biomarkers for these pathways and examine them in longitudinal studies of patients in different stages of the disease. Here, we discuss targeted proteomic approaches to study AD and AD-related pathologies in closer detail and explorative approaches to discover novel pathways that may contribute to the disease. This article is part of a Special Issue entitled: Neuroproteomics: Applications in neuroscience and neurology.

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