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Serum tau fragments predict return to play in concussed professional ice hockey players.

Journal article
Authors Pashtun Shahim
Thomas Linemann
Dilek Inekci
Morten Asser Karsdal
Kaj Blennow
Yelverton Tegner
Henrik Zetterberg
Kim Henriksen
Published in Journal of neurotrauma
Volume 33
Issue 22
Pages 1995-1999
ISSN 1557-9042
Publication year 2016
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 1995-1999
Language en
Subject categories Neurochemistry


The diagnosis of sports-related concussion is mainly based on subjective clinical symptoms and neuropsychological tests. Thus, reliable brain injury biomarkers to assess when it is safe to return to play are highly desirable. The overall objective of this study was to evaluate the utility of two newly described tau fragments for diagnosis and prognosis of sports-related concussions Materials and Methods: This multicenter prospective cohort study involved all 12 teams of the top professional ice hockey league in Sweden. A total of 288 players consented to participate in the study. Thirty-five players sustained concussions, of whom 28 underwent repeated blood samplings at 1, 12, 36, and 144 hours after the trauma, or when the player returned to play (7- > 90 days).

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